Shock Treatment

Interesting new treatment being tried out for melanoma. When used with gene therapy, shocking the tumours has had good results in clinical trials. Other than the discomfort of a 6-second electric shock, there are no known major side-effects.

From ABC 7 in Chicago:

Researchers are now focusing on gene therapy for melanoma patients. The challenge has been getting the gene into the tumor. The overall goal is for the gene to stimulate the immune system to fight the cancer. For the first time, researchers are using electroporation on humans to deliver gene therapy in melanoma patients.

Electroporation involves the use of a handheld device with a number of prongs on the end of it. The device is put into the tumor on the skin and delivers electricity. Researchers say this stimulation opens up pores in the tumor cell membrane, allowing small molecules called DNA plasmids to get inside the tumor before the tumor membrane pores close again. These plasmids contain the gene for interleukin-12. Adil Daud, M.D., an oncologist at Moffitt Cancer Center in Tampa says, "It will be like a flag that says danger or warning to the immune system and cause the immune system to destroy that tumor."
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The first clinical trials began in 2005. So far, seven patients with stage four melanoma have been treated with electroporation. Dr. Daud says the purpose of this study is to see if it is safe for the patient. However, they are encouraged by the findings thus far.
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There are no major side effects associated with this treatment; however, one downside is discomfort for the patient. The treatment involves shocking the patient's tumor for six seconds for each treatment.